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[(lipid)-270.8(metabolism,)-267.1(depending)-271.6(on)-267.1(the)-263.8(genotype)-270.5(for)-268.2(the)-269.5(studied)]TJ
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[(SNPs.)-353.8(It)-353.6(was)-356.5(found)-351.1(that)-357.2(in)-347.9(overweight)-360(children,)-354.6(Ser447Ser)]TJ
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[(homozygotes)-274.8(of)-272.9(the)]TJ
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1.9871 0 TD
[(gene,)-275.1(the)-275.3(level)-273(of)-272.9(TGs)-270.1(in)-273(the)-275.3(blood)]TJ
-10.212 -1.1116 TD
[(serum)-433.9(is)-434.1(2.3)-426.1(times)-434.2(higher)-434.1(than)-431.9(in)-434.3(children)-431.8(with)-431.7(the)-430.8(same)]TJ
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[(genotype)-437.5(from)-437.5(the)-436.6(control)-441.1(group)-437.5(\(Table)-436.4(4\).)-437.6(In)-434.1(Ser447Ter)]TJ
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[(heterozygotes)-307(with)-305(excess)-309.2(weight,)-306.1(the)-304.1(level)-307.6(of)-301.7(TGs)-304.7(exceeds)]TJ
T*
[(the)-281.1(control)-285.6(values)-279.6(by)-278.7(only)-281(13%)-280.8(\(Table)-286.7(4\).)]TJ
1.0137 -1.1116 TD
[(Elevated)-278.7(serum)-278.4(TG)-275(levels)-279.7(in)-278.8(overweight)-279.4(children)-276.3(are)-276.3(also)]TJ
-1.0137 -1.1174 TD
[(associated)-280.5(with)-276.2(the)]TJ
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7.9599 0 TD
(AA)Tj
/F4 1 Tf
1.5033 0 TD
(and)Tj
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1.7222 0 TD
(AT)Tj
/F4 1 Tf
1.4399 0 TD
[(genotypes)-277.1(of)-272.9(the)-275.3(rs99305069)]TJ
-12.6253 -1.1116 TD
[(polymorphism)-280.7(of)-284.4(the)]TJ
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8.749 0 TD
(FTO)Tj
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2.1656 0 TD
[(gene)-283.2(\(Table)-280.9(5\).)]TJ
-9.9009 -1.1116 TD
[(In)-186.5(both)-194.6(study)-189.8(groups)-190.7(of)-192.2(children,)]TJ
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13.0169 0 TD
(Gln192Arg)Tj
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4.6884 0 TD
(heterozygotes)Tj
-18.719 -1.1174 TD
[(of)-215.3(the)]TJ
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(PON1)Tj
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[(gene)-219.8(are)-218.7(characterized)-224.2(by)-215.3(a)-221.1(higher)-215.2(level)-221.2(of)-215.3(HDL)]TJ
-5.2125 -1.1116 TD
[(compared)-503.1(with)]TJ
/F5 1 Tf
6.7389 0 TD
(GlnGln)Tj
/F4 1 Tf
3.4961 0 TD
[(homozygotes)-499.4(\(Table)-499.8(6\).)-500.9(Children)]TJ
-10.235 -1.1116 TD
[(with)-189.8(different)-191(BMI,)-187.2(but)-187.7(the)-188.9(same)-192.1(genotype)-189.8(for)-187.5(the)]TJ
/F5 1 Tf
19.7097 0 TD
(PON1)Tj
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2.684 0 TD
(gene)Tj
-22.3937 -1.1174 TD
[(polymorphism,)-439.6(have)-438.7(a)-434.2(similar)-442.2(level)-440.1(of)-434.1(HDL)-438.2(in)-434.3(the)-436.6(blood)]TJ
0 -1.1116 TD
(serum.)Tj
1.0137 -1.1116 TD
[(Analysis)-304.5(of)-295.9(intergenic)-302.8(interaction)-10.3(s)-294.6(revealed)-307.3(a)-301.8(statistically)]TJ
-1.0137 -1.1116 TD
[(signicant)-191.9(two-locus)-196.3(model)-192.3(that)-190.1(includes)-195.5(polymorphic)-193.3(loci)-190.1(of)]TJ
0 -1.1174 TD
(the)Tj
/F5 1 Tf
1.5263 0 TD
(LPL)Tj
/F4 1 Tf
2.0159 0 TD
(and)Tj
/F5 1 Tf
1.7452 0 TD
(FTO)Tj
/F4 1 Tf
2.1829 0 TD
[(genes)-301.4(\(Table)-298.2(7\).)-299.3(The)-299.4(studied)-296.9(model)-301.8(has)-298(a)]TJ
-7.4703 -1.1116 TD
[(high)-281(predictive)-285.6(ability.)]TJ
1.0137 -1.1116 TD
[(A)-503.1(two-lo)-7.7(cus)-505.4(genotype)]TJ
/F5 1 Tf
9.8606 0 TD
[(FTO)-512.1(AT/LPL)-504(SerTer)]TJ
/F4 1 Tf
9.2904 0 TD
(associated)Tj
-20.1647 -1.1174 TD
[(with)-293.5(a)-290.2(reduced)-299.2(risk)-292.3(of)-290.2(overweight)-296.7(in)-290.3(children)-293.6(was)-293.1(identied)]TJ
0 -1.1116 TD
(\()Tj
/F13 1 Tf
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(w)Tj
/F4 1 Tf
7.3823 0 0 6.5614 70.7527 367.9936 Tm
(2)Tj
9.843 0 0 9.843 77.2157 363.6283 Tm
(4.88,)Tj
/F5 1 Tf
2.2808 0 TD
(p)Tj
/F6 1 Tf
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(=)Tj
/F4 1 Tf
.72 0 TD
[(0.027;)-279.8(OR)]TJ
/F6 1 Tf
4.3659 0 TD
(=)Tj
/F4 1 Tf
.72 0 TD
[(0.35;)-278.7(95%)-280.8(CI)-279.7(0.150.83\))-280.6(\(Fig.)-284.2(1\).)]TJ
-9.2789 -1.1116 TD
-.0158 Tc
[(Chil)-15.8(d)10.7(r).4(en)-293.4(and)-293.4(a)-.8(do)-15.8(l)10.7(e)-.8(sce)-15.8(n)9.6(ts)-293.2(with)-293.4(the)]TJ
/F5 1 Tf
13.6102 0 TD
-.0162 Tc
[(FTO)-294.6(A)-1.2(T/)-16.2(L)10.4(P)-1.2(L)-287.8(S)-16.2(e)9.2(rTe)-16.2(r)]TJ
/F4 1 Tf
8.4149 0 TD
0 Tc
[(ge)25.4(-)]TJ
-23.0388 -1.1174 TD
-.016 Tc
[(no)-16(t)10.5(ype)-214.1(d)-16(o)-202.5(not)-213.1(di)-16(f)10.5(f).2(er)-218.7(from)-214.2(c)-16(h)9.4(ildr)-16(e)9.5(n)-212.9(o).2(f)-212.9(t)-16(h)10.5(e)-214.1(con)-16(t)10.5(rol)-213.1(g)-16(r)10.6(oup)-218.7(in)-212.9(ter)-16(m)9.4(s)]TJ
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-.0157 Tc
[(of)-281.7(bi)-15.7(o)10.8(c)-.7(hem)-15.7(i)9.5(cal)-281.9(par)-15.7(a)9.8(mete)-15.7(r)9.8(s)-281.5(o).5(f)-281.7(lip)-15.7(i)10.8(d)-281.7(metab)-15.7(o)10.9(lis)-15.7(m)-266.6(\().5(T)-15.7(a)8.5(ble)-282.9(8).5(\))-15.7(.)]TJ
/F8 1 Tf
8.9663 0 0 8.9663 62.022 305.1779 Tm
0 Tc
(Discussion)Tj
/F4 1 Tf
9.843 0 0 9.843 72 288.7369 Tm
[(We)-189.9(studied)-193.2(the)-194.7(frequencies)-195.2(of)-192.2(genotypes)-190.7(and)-194.5(alleles)-189.9(of)-192.2(four)]TJ
-1.0137 -1.1116 TD
[(SNPs)-240.9(of)-238.3(genes,)-241.5(the)-240.7(protein)-245.2(products)-240.3(of)-238.3(which)-243.8(are)-241.7(involved)-240.6(in)]TJ
T*
[(lipid)-483.9(metabolism.)-486(The)-483.7(obtained)-483.7(minor)-484.9(alleles)-483.7(frequencies)]TJ
0 -1.1174 TD
[(\(MAF\))-295(correspond)-301.1(to)-290.3(the)-298.3(data)-294.8(for)-291.2(other)-300.5(populations)-295.7(of)-290.2(Cau-)]TJ
0 -1.1116 TD
[(casians.)-486.7(For)-481.2(the)]TJ
/F5 1 Tf
7.2054 0 TD
(Gln192Arg)Tj
/F4 1 Tf
4.9821 0 TD
[(polymorphism)-488(of)-480.2(the)]TJ
/F5 1 Tf
9.3538 0 TD
(PON1)Tj
/F4 1 Tf
2.4997 0 TD
(,)Tj
-24.041 -1.1116 TD
[(MAF)-367.8(is)-365(0.25)-363.8(for)-366.1(residents)-369.2(of)-359.3(Brazi)-9(l)-364.1(\(Barris-Oliveira)]TJ
/F5 1 Tf
21.9157 0 TD
[(et)-366.4(al.)]TJ
/F4 1 Tf
2.1253 0 TD
(,)Tj
1.463 38.7801 TD
[(2012\);)-214.1(0.31)-214.1(for)-210.6(residents)-213.7(of)-215.3(Pakistan)-212.6(\(Idrees)]TJ
/F5 1 Tf
17.5901 0 TD
[(et)-210.8(al.)]TJ
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1.9698 0 TD
[(,)-210.8(2018\);)-214.1(and)]TJ
-19.56 -1.1116 TD
[(0.38)-375.4(among)-376.5(Caucasians)-379.3(of)-370.8(European)-380.9(descent)-374(\(Pauer)]TJ
/F5 1 Tf
21.9099 0 TD
[(et)-372.1(al.)]TJ
/F4 1 Tf
2.1368 0 TD
(,)Tj
-24.0468 -1.1174 TD
[(2010\).)-273.9(In)-267.1(India,)-269.4(MAF)-269.9(is)-272.8(higher0.470.51)-272.3(among)-267.1(residents)]TJ
0 -1.1116 TD
[(of)-405.3(different)-398.3(regions)-406.2(\()-81.7(Mitra)]TJ
/F5 1 Tf
11.4906 0 TD
[(et)-400.9(al.)]TJ
/F4 1 Tf
2.1599 0 TD
[(,)-400.8(2015\).)-394.8(In)-405.3(our)-394.9(study,)-406.3(the)]TJ
-13.6505 -1.1116 TD
[(MAF)-373.5(for)-366.1(the)]TJ
/F5 1 Tf
5.656 0 TD
(Gln192Arg)Tj
/F4 1 Tf
4.8669 0 TD
[(polymorphism)-367.1(of)-370.8(the)]TJ
/F5 1 Tf
9.0082 0 TD
(PON1)Tj
/F4 1 Tf
2.8683 0 TD
(gene)Tj
-22.3995 -1.1174 TD
[(was)-287.4(0.29.)]TJ
1.0137 -1.1116 TD
[(The)-287.9(frequency)-289.8(of)]TJ
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7.2687 0 TD
(-250A)Tj
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2.7301 0 TD
[(allele)-292.7(of)-284.4(the)]TJ
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5.1089 0 TD
(LIPC)Tj
/F4 1 Tf
2.4536 0 TD
[(is)-290.1(0.32)-283.2(among)]TJ
-18.5751 -1.1116 TD
[(Brazi)-9(lians)-496.3(\(de)-499.8(Andrade)]TJ
/F5 1 Tf
10.2926 0 TD
[(et)-498.8(al.)]TJ
/F4 1 Tf
2.2578 0 TD
[(,)-498.8(2004\);)-496.3(and)-494(0.28)-502.1(and)-494(0.39)]TJ
-12.5504 -1.1116 TD
[(among)-267.1(residents)-265.5(of)-261.4(various)-262.2(China)-261.3(provinces)-265.6(\(Li)-263.8(Meng)]TJ
/F5 1 Tf
22.0251 0 TD
[(et)-262.7(al.)]TJ
/F4 1 Tf
2.0217 0 TD
(,)Tj
-24.0468 -1.1174 TD
[(2010\).)-250.8(In)-244.1(India,)-246.3(the)-246.5(MAF)-241.1(is)-249.8(0.05)-242.9(\(Verma)]TJ
/F5 1 Tf
16.5534 0 TD
[(et)-245.4(al.)]TJ
/F4 1 Tf
2.0044 0 TD
[(,)-245.3(2016\).)-245.1(In)-244.1(our)]TJ
-18.5578 -1.1116 TD
[(study,)-204.7(the)-206.2(MAF)-200.7(for)]TJ
/F5 1 Tf
7.7756 0 TD
(-250G)Tj
/F6 1 Tf
2.5573 0 TD
(>)Tj
/F5 1 Tf
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(A)Tj
/F4 1 Tf
.8179 0 TD
[(SNP)-205.4(of)-198(the)]TJ
/F5 1 Tf
4.4926 0 TD
(LIPC)Tj
/F4 1 Tf
2.3672 0 TD
[(was)-201(0.23.)-206(This)]TJ
-18.5578 -1.1116 TD
[(value)-486(is)-486(lower)-485.7(than)-483.8(in)-486.1(other)-484.8(studies)-486.8(for)-481.3(Caucasians)-494.5(with)]TJ
0 -1.1174 TD
(MAF)Tj
/F6 1 Tf
2.3269 0 TD
(=)Tj
/F4 1 Tf
.72 0 TD
[(0.387)-278.5(\(Liao)]TJ
/F5 1 Tf
4.9879 0 TD
[(et)-280(al.)]TJ
/F4 1 Tf
2.0389 0 TD
[(,)-279.9(2021\).)]TJ
-9.06 -1.1116 TD
[(According)-191.8(to)-180.9(rs99305069)-189.3(of)-186.5(the)]TJ
/F5 1 Tf
12.7174 0 TD
(FTO)Tj
/F4 1 Tf
1.8892 0 TD
[(,)-182(MAF)-189.2(in)-186.6(our)-181.8(data)-191.2(was)]TJ
-15.6203 -1.1116 TD
[(0.59.)-327(This)-322.3(value)-324.7(is)-324.7(higher)-324.7(compared)-324.5(with)-328.1(the)-321.4(data)-323.6(for)-325.8(other)]TJ
0 -1.1174 TD
[(populations)-376.3(of)-370.8(Caucasians.)-377(Among)-376.2(non-Hispanic)-373.6(whites)-371.6(in)]TJ
0 -1.1116 TD
[(the)-263.8(United)-268.1(States,)-259.9(the)-263.8(MAF)-264.1(was)-264.3(0.39)-260.2(\(Hallman)]TJ
/F5 1 Tf
19.1798 0 TD
[(et)-262.7(al.)]TJ
/F4 1 Tf
2.0217 0 TD
[(,)-256.9(2012\).)]TJ
-21.2015 -1.1116 TD
[(In)-434.1(the)-436.6(group)-431.7(of)-428.4(children)-437.6(in)-434.3(Germany,)-436(the)-430.8(MAF)-436.9(was)-431.4(0.44)]TJ
T*
.0875 Tc
[(\(M)87.5(u)]TJ
1.3881 .0058 TD
0 Tc
()Tj
.4147 -.0058 TD
(ller)Tj
/F5 1 Tf
1.5839 0 TD
[(et)-239.6(al.)]TJ
/F4 1 Tf
1.9986 0 TD
[(,)-239.6(2008\).)-239.3(The)-236(MAF)-241.1(among)-238.3(Iranian)-246.2(residents)-242.5(was)]TJ
-5.3853 -1.1174 TD
[(0.45)-415.7(\()-87.5(Mehrdad)]TJ
/F5 1 Tf
6.6121 0 TD
[(et)-418.2(al.)]TJ
/F4 1 Tf
2.1772 0 TD
[(,)-412.4(2020\).)-412.1(The)-420.4(average)-415.5(MAF)-413.9(value)-416.9(for)]TJ
-8.7893 -1.1116 TD
[(Caucasians)-298.7(is)-290.1(0.44)-289(\(Elouej)]TJ
/F5 1 Tf
11.0529 0 TD
[(et)-291.5(al.)]TJ
/F4 1 Tf
2.0505 0 TD
[(,)-285.6(2016\).)-291.1(Among)-295.6(Asians,)-294(the)]TJ
-13.1033 -1.1116 TD
[(frequency)-209.2(of)-203.8(the)]TJ
/F5 1 Tf
6.687 0 TD
(A)Tj
/F4 1 Tf
.8179 0 TD
[(allele)-206.3(of)-209.5(the)]TJ
/F5 1 Tf
4.8612 0 TD
(FTO)Tj
/F4 1 Tf
2.0908 0 TD
[(is)-203.7(lower.)-206.9(For)-204.7(example,)-206.1(in)]TJ
-14.4569 -1.1174 TD
[(China)-7.8(,)-302.9(the)-309.9(MAF)-310.2(was)-310.4(0.22)-312(\(Xi)]TJ
/F5 1 Tf
12.5216 0 TD
[(et)-308.8(al.)]TJ
/F4 1 Tf
2.0677 0 TD
[(,)-308.7(2010\).)-308.4(Thus,)-314.1(the)-309.9(MAF)]TJ
-14.5893 -1.1116 TD
[(value)-284.4(we)-280.7(identied)-283.2(for)-285.5(rs99305069)-281.5(is)-278.6(one)-280.9(of)-278.6(the)-281.1(highest.)]TJ
1.0137 -1.1116 TD
[(The)-282.1(MAF)-275.6(for)-279.7(the)]TJ
/F5 1 Tf
7.2284 0 TD
(Ser447Ter)Tj
/F4 1 Tf
4.4983 0 TD
[(SNP)-280.3(of)-278.6(the)]TJ
/F5 1 Tf
4.7172 0 TD
(LPL)Tj
/F4 1 Tf
1.9986 0 TD
[(in)-278.8(our)-279.7(study)]TJ
-19.4563 -1.1174 TD
[(was)-431.4(0.08.)-430.6(This)-426(frequency)-433.8(of)-428.4(the)-430.8(allele)-430.9(corresponds)-434.4(to)-428.5(the)]TJ
0 -1.1116 TD
[(literature)-251.1(data.)-252.2(Thus,)-245(among)-249.8(the)-246.5(residents)-248.2(of)-244.1(Kazakhstan,)-256.1(the)]TJ
T*
[(MAF)-367.8(was)-362.2(0.14)-363.8(\(Shakhanova)]TJ
/F5 1 Tf
12.1415 0 TD
[(et)-366.4(al.)]TJ
/F4 1 Tf
2.1253 0 TD
[(,)-366.3(2020\),)-360.3(among)-365(the)-367.5(resi-)]TJ
-14.2668 -1.1174 TD
[(dents)-323.4(of)-324.7(Saudi)-323.4(Arabia0.05)-324.1(\(Daoud)]TJ
/F5 1 Tf
15.3208 0 TD
[(et)-320.3(al.)]TJ
/F4 1 Tf
2.0793 0 TD
[(,)-326(2013\),)-319.9(in)-319.1(India,)]TJ
-17.4001 -1.1116 TD
[(the)-286.8(MAF)-281.4(was)-281.6(0.0960.15)-280.6(\(Ayyappa)]TJ
/F5 1 Tf
14.7909 0 TD
[(et)-280(al.)]TJ
/F4 1 Tf
2.0389 0 TD
[(,)-279.9(2017\).)]TJ
-15.8162 -1.1116 TD
[(The)-195.7(study)-195.5(group)-195.5(of)-192.2(overweight)-198.8(children)-195.7(is)-192.2(characterized)-201.2(by)]TJ
-1.0137 -1.1116 TD
[(an)-492.9(increased)-498.3(level)-491.9(of)-491.7(TGs)-489(and)-494(LDL)-490.4(in)-491.9(the)-494.2(blood)-489.5(serum)]TJ
0 -1.1174 TD
[(compared)-410.9(with)-408.7(the)-402(control)-406.5(group.)-406.3(Changes)-408.3(in)-405.5(the)-407.8(level)-405.5(of)]TJ
0 -1.1116 TD
[(these)-445.5(biochemical)-450.4(parameters)-443(may)-443.4(be)-446.9(associated)-447.5(with)-443.3(the)]TJ
9.843 0 0 9.843 313.0582 243.0992 Tm
[(pecul)-8(iarities)-299.4(of)-301.7(the)-304.1(functioning)-301.6(of)-301.7(lipoprotein)-301.8(lipase.)-306.2(LPL)-299.3(is)]TJ
0 -1.1174 TD
[(an)-193.4(enzyme,)-187.6(the)-188.9(concentration)-192.1(and)-188.8(activity)-190.2(of)-186.5(which)-192(determine)]TJ
0 -1.1116 TD
[(the)-442.3(risk)-442(of)-439.9(metabolic)-447(disorders)-442.7(related)-443.4(to)-440.1(energy)-440.9(balance,)]TJ
T*
[(insulin)-272.8(action,)-271.8(and)-269.4(body)-269.3(weight)-273.9(regulation.)-276.3(In)-267.1(the)]TJ
/F5 1 Tf
20.159 0 TD
(LPL)Tj
/F4 1 Tf
1.9871 0 TD
(gene,)Tj
-22.1461 -1.1174 TD
[(we)-286.5(considered)-285.1(the)]TJ
/F5 1 Tf
7.5855 0 TD
(Ser447Stop)Tj
/F4 1 Tf
4.8958 0 TD
[(\(rs328\))-278.1(polymorphism.)]TJ
-11.4676 -1.1116 TD
[(According)-422.1(to)-422.8(the)-419.3(results)-417.6(of)-422.6(our)-418(study,)-417.8(the)-419.3(frequency)-422.3(of)]TJ
-1.0137 -1.1116 TD
[(heterozygot)-10.1(es)-354.5(for)-354.6(the)]TJ
/F5 1 Tf
9.0312 0 TD
(Ser447Ter)Tj
/F4 1 Tf
4.5732 0 TD
[(polymorphis)-7.6(m)-353.7(o)0(f)-353.5(the)]TJ
/F5 1 Tf
8.9736 0 TD
(LPL)Tj
/F4 1 Tf
-22.578 -1.1116 TD
[(gene)-277.4(among)-267.1(children)-276.3(in)-273(Rostov-on-Don)-269.5(was)-275.9(1516%.)-270.3(There)]TJ
0 -1.1174 TD
[(was)-350.7(no)-347.8(association)-355.4(of)-347.7(this)-344.3(SNP)-349.4(with)-351.1(changes)-350.8(in)-347.9(the)-350.2(risk)-344.1(of)]TJ
0 -1.1116 TD
[(overweight.)-346.2(This)-339.6(polymorphism)-338.3(is)-336.2(located)-345.5(in)-336.4(exon)-339.6(9)-335.2(o)0(f)-342(the)]TJ
/F5 1 Tf
T*
(LPL)Tj
/F4 1 Tf
1.7222 0 TD
[(,)-320.2(i)0(n)-319.1(which)-324.5(replacing)-324.7(C)-318.9(with)-322.3(G)-324.5(leads)-324.6(to)-319.1(premature)-325.7(com-)]TJ
-1.7222 -1.1174 TD
[(pletion)-331.8(of)-330.5(reading.)-330.3(The)-328.2(result)-336.1(is)-324.7(a)-330.6(truncated)-330.4(protein)-331.6(lacking)]TJ
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[(two)-211.7(carboxyl)-218.6(terminal)-214.3(amino)-209.6(acids.)-212.8(The)-213(frequency)-214.9(of)-209.5(carriers)]TJ
T*
[(of)-405.3(this)-401.9(genetic)-403.1(variant)-401.9(is)-399.5(from)-403(10%)-401.8(to)-399.7(25%)-401.8(\(Fisher)]TJ
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T*
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[(,)-302.9(2015\).)-296.9(The)-305.2(data)-300.6(ob-)]TJ
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[(tained)-274.1(by)-267.1(us)-272.7(indirectly)-273(conrm)-268(the)-275.3(possible)-269(protective)-274(effect)]TJ
ET
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62.022 652.138 490.167 .22681 re
f
62.022 690.803 490.167 .28345 re
f
BT
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ET
62.022 193.266 239.131 .28348 re
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62.022 78.179 239.131 .22681 re
f
62.022 174.387 239.131 .28342 re
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62.022 156.699 239.131 .28348 re
f
BT
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T*
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[(Odds)-332.8(ratio)-11028.3(3.24)-328.8(\(1.427.39\))]TJ
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T*
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(2)Tj
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[(\))-12808(8.6)-333.6(\()]TJ
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15.2198 0 TD
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[(Precision)-14079.4(0.92)]TJ
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[(FTO)-331.6(genes.)]TJ
/F8 1 Tf
8.9663 0 0 8.9663 62.022 749.6502 Tm
(422)Tj
46.2837 0 TD
[(KULAEVA)-335.2(ET)-338.7(AL.)]TJ
ET
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9.843 0 0 9.843 59.7543 407.3952 Tm
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10.3963 0 TD
(Ser447Ter)Tj
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T*
[(blood)-184.2(serum)-186.2(is)-180.7(42%)-182.9(lower)-180.4(compared)-186.3(with)-184.1(homozygotes)-182.6(of)-180.7(the)]TJ
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(SerSer,)Tj
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T*
[(multifactorial)-285.8(control)-285.6(of)-278.6(TG)-280.7(levels.)]TJ
1.0137 -1.1174 TD
(SNP)Tj
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[(with)-362.6(a)-359.4(predisposition)-368(to)-359.4(type)-357(2)-364(diabetes.)-361.4(However,)-366.5(there)-359.3(is)]TJ
T*
[(strong)-294.5(evidence)-301.6(that)-293.8(this)-292.4(polymorphism)-292.2(affects)-299.1(the)-292.6(accumu-)]TJ
0 -1.1174 TD
[(lation)-284.6(of)-278.6(fat)-281(in)-284.6(the)-281.1(human)-278.6(body)-280.9(\(Frayling)]TJ
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16.899 0 TD
[(et)-285.7(al.)]TJ
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[(,)-279.9(2007\).)]TJ
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[(allele)-194.8(of)-186.5(the)]TJ
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[(is)-186.4(associated)-194.1(with)-189.8(an)]TJ
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[(allele)-327.3(of)-324.7(the)]TJ
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[(with)-322.3(an)-325.9(increased)-325.5(risk)-326.8(of)-324.7(overweight)-325.5(was)]TJ
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10.212 0 TD
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[(genotypes)-213.8(compared)-215.1(with)]TJ
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[(the)-281.1(control)-285.6(group.)]TJ
1.0137 -1.1174 TD
(Rutters)Tj
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3.116 0 TD
[(et)-222.4(al.)]TJ
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[(\(2011\))-219.7(studied)-227.8(58)-221.1(boys)-223.1(aged)-219.8(1217)-224.4(years)-226.5(and)]TJ
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[(identied)-369.6(an)-366.2(association)-366.9(of)-365(the)]TJ
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(A)Tj
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[(allele)-367.6(\(rs9939609\))-368.9(of)-359.3(the)]TJ
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(FTO)Tj
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[(with)-449(a)-445.8(high)-448(BMI,)-452.1(obesity,)-444.3(and)-448(high)-448(leptin)-451.7(levels)-446.7(in)]TJ
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[(children)-236(aged)-231.4(12)-232.6(and)-234.9(1517)-230.1(years.)-235.7(In)-226.8(boys)-234.6(aged)-231.4(1314)-230.1(years,)]TJ
0 -1.1116 TD
[(the)-200.4(association)-199.9(was)-201(not)-193.5(observed,)-204.4(which)-197.7(was)-195.2(explained)-203.7(by)-192.3(the)]TJ
T*
[(onset)-334.9(of)-330.5(puberty,)-335(accompanied)-336.1(by)-330.5(endocrine)-330.3(changes)-333.6(and)-332.8(a)]TJ
T*
[(drop)-217.5(in)-215.4(leptin)-215.5(levels)-216.3(relative)-214.2(to)-215.4(fat)-217.7(mass)-213.8(\(Rutters)]TJ
/F5 1 Tf
19.272 0 TD
[(et)-216.6(al.)]TJ
/F4 1 Tf
1.9756 0 TD
[(,)-210.8(2011\).)]TJ
4.2622 56.7734 TD
[(Such)-368.3(data)-375.5(indicate)-369.8(the)-373.2(need)-369.6(to)-370.9(take)-369.7(into)-373.3(account)-374.2(age)-368.5(char-)]TJ
0 -1.1174 TD
[(acteristics,)-308.3(as)-302.7(well)-306.2(as)-302.7(the)-298.3(degree)-309.6(of)-301.7(maturation)-302.9(of)-301.7(the)-304.1(repro-)]TJ
0 -1.1116 TD
[(ductive)-701.5(system)-699.9(when)-703.4(analyzing)-699.1(the)-701.5(genetic)-702.6(causes)-706.6(of)]TJ
T*
[(overweight)-446.4(in)-451.6(children)-449.1(and)-448(adolescents.)-452(In)-445.7(our)-446.8(study,)-446.6(the)]TJ
T*
[(analysis)-345.1(of)-336.2(the)-344.4(frequencies)-345(of)-342(genotypes)-340.5(and)-338.5(alleles)-345.5(for)-343.1(the)]TJ
0 -1.1174 TD
[(studied)-308.4(SNPs,)-307.7(depending)-311.9(on)-307.5(the)-309.9(age)-310.9(of)-307.4(children,)-314.3(did)-308.7(not)-308.7(re-)]TJ
0 -1.1116 TD
[(veal)-283.3(statistically)-283.3(signicant)-284.1(differences.)]TJ
1.0137 -1.1116 TD
[(In)-497.5(our)-504.4(work,)-498.3(none)-500.9(of)-503.3(the)-499.9(four)-505.4(studied)-504.3(polymorphisms)]TJ
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[(showed)-267.6(an)-268.3(individual)-271.9(association)-269(with)-270.5(changes)-270.2(in)-267.3(the)-269.5(risk)-269.2(of)]TJ
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[(overweight)-406.1(in)-399.7(children.)-406.5(Analysis)-408.1(of)-399.6(intergenic)-406.5(interactions)]TJ
T*
[(revealed)-226.7(a)-221.1(two-locus)-225.1(genotype)-224.4(associated)-228.6(with)-224.4(a)-226.9(reduced)-224.3(risk)]TJ
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[(of)-342(overweight.)-351.9(This)-345.4(genotype)-345.3(is)-347.7(conditioned)-348.9(by)-342(the)-344.4(hetero-)]TJ
0 -1.1116 TD
[(zygous)-353.2(state)-353.5(for)-354.6(the)-355.9(rs9939609)-355.3(of)-353.5(the)]TJ
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15.8219 0 TD
(FTO)Tj
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2.2405 0 TD
[(and)-355.8(the)-350.2(hetero-)]TJ
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[(zygous)-433.8(state)-434.1(of)-434.1(the)]TJ
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8.4668 0 TD
(Ser447Ter)Tj
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4.6538 0 TD
[(polymorphism)-430.4(of)-434.1(the)]TJ
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9.1982 0 TD
(LPL)Tj
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(.)Tj
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[(Children)-374.1(with)-374.2(this)-367.3(genotype)-374.1(do)-370.8(not)-372.1(differ)-376.4(from)-374.2(the)-367.5(control)]TJ
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[(group)-351.1(in)-353.7(terms)-353.4(of)-353.5(biochemical)-358.2(parameters)-356.6(of)-353.5(lipid)-357.2(metabo-)]TJ
0 -1.1116 TD
[(lism.)-337.4(This)-345.4(may)-339.8(be)-343.2(due)-338.5(to)-342.1(the)-338.7(increased)-342.8(activity)-345.7(of)-342(the)-338.7(LPL)]TJ
T*
[(enzyme)-236(in)-232.7(the)-229.2(presence)-237.9(of)-232.6(the)-235(447Ter)-233.6(mutation)-230.5(of)-232.6(the)]TJ
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21.5586 0 TD
(LPL)Tj
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[(heterozygotes.)-241.3(A)-243.9(twofold)-239.2(increase)-243.8(in)-238.5(LPL)-241.7(activity)-242(during)-242.9(the)]TJ
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[(cleavage)-435.2(of)-428.4(amino)-434.2(acids)-434(at)-429.7(the)-430.8(C-terminus)-434.9(of)-428.4(the)-436.6(peptide)]TJ
T*
[(molecule)-186.6(was)-189.5(shown)-184.7(by)-186.5(Kozaki)]TJ
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12.6656 0 TD
[(et)-187.8(al.)]TJ
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2.1311 0 TD
[(\(1993\).)-188.5(This)-184.1(mutation)-190.2(is)]TJ
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[(associated)-389.9(with)-385.7(an)-383.5(increase)-387.7(in)-388.2(HDL)-386.4(and)-384.6(a)-382.4(decrease)-388.8(in)-388.2(TG)]TJ
0 -1.1116 TD
(\(Kuivenhoven)Tj
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6.0477 0 TD
[(et)-320.3(al.)]TJ
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2.0793 0 TD
[(,)-314.5(1997\).)-319.9(Individuals)-324.5(with)-316.6(the)]TJ
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11.9456 0 TD
(Ser447Ter)Tj
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[(mutation)-311.1(have)-312(a)-307.5(signicantly)-315.2(larger)-314.3(LDL)-311.8(particle)-312.2(size)-311.9(com-)]TJ
0 -1.1174 TD
[(pared)-364.9(with)-368.4(those)-369.5(with)-368.4(the)]TJ
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10.9665 0 TD
(SerSer)Tj
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3.0354 0 TD
[(genotype)-368.4(\(Sawano)]TJ
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7.9138 0 TD
[(et)-366.4(al.)]TJ
/F4 1 Tf
2.1253 0 TD
(,)Tj
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[(2001\).)-366(Thus,)-371.7(the)]TJ
/F5 1 Tf
7.1708 0 TD
(Ser447Ter)Tj
/F4 1 Tf
4.5905 0 TD
[(mutation)-368.7(can)-374.2(contribute)-370.8(to)-370.9(the)]TJ
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[(normalization)-284.5(of)-278.6(the)-281.1(blood)-282.1(lipid)-282.4(prole.)]TJ
1.0137 -1.1116 TD
[(On)-221.9(the)-223.5(contrary,)-222(a)-226.9(number)-222.1(of)-226.8(data)-220(indicate)-231.6(the)-223.5(existence)-227.7(of)]TJ
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[(a)-278.7(relationship)-280.8(between)-277.1(lipid)-276.6(metabolism)-280.9(indicators)-284.2(and)]TJ
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22.4053 0 TD
(FTO)Tj
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[(rs9939609)-326.5(\(Khella)]TJ
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7.885 0 TD
[(et)-326(al.)]TJ
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[(,)-326(2017\).)-325.7(It)-330.6(has)-326.8(been)-329.3(shown)-334.5(that)-328.4(the)]TJ
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[(presence)-260.9(of)-261.4(a)-255.7(risk)-257.7(allele,)-261.6(especially)-263.5(in)-261.5(the)-258(homozygous)-260.9(state,)]TJ
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[(leads)-197.8(to)-203.9(a)-198.1(decrease)-204.5(in)-198.2(the)-200.4(level)-198.2(of)-198(HDL)-202.1(\(Franczak)]TJ
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19.6003 0 TD
[(et)-199.3(al.)]TJ
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1.9583 0 TD
[(,)-199.3(2018:)]TJ
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(Mehrdad)Tj
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3.859 0 TD
[(et)-251.2(al.)]TJ
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[(,)-245.3(2020\).)-250.8(In)-249.8(our)-245.2(study,)-250.8(there)-249.8(was)-247(no)-249.9(association)]TJ
9.843 0 0 9.843 310.8472 363.5149 Tm
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